During my more than fifty years of active involvement in virology and retrovirology I went through different phases in which I dealt with various viruses. They included poxviruses, paramyxoviruses, or rhabdoviruses. Each of these families of viruses taught me a new lesson that I utilized working with the most attractive virus family for me – retroviruses. Therefore, the idea to connect general virology with retrovirology is close to my heart. There are a series of interconnections between both these fields when inspected from the point of view of construction of vectors suitable for transmission of required genetic information. We are also gaining better insight into the cellular functions the lack of which or activation of which keep in check the outcome of virus infection. Par excellence retroviruses, but potentially other viruses, constitute an important part of human and animal genomes and can provide new functions, such as triggering syncytiotrophoblast formation and opening new ways to expression of some genes yielding splicing signals. Speaking about retroviruses I should underline the significance of retroelements and sequences amplified by reverse transcription, which together constitute the majority of our DNA genome. Needles to say, we are at the beginning of understanding the significance of these processes for our genome shaping and functionality. I believe that this new flexible journal will become an important orientation point in our field.