Multiple Food Additives Enhance Human Chronic Diseases

Over recent decades, a significant increase in the incidence of chronic immune mediated diseases in industrialized countries has led to the postulation that diet is a potential environmental risk factor for such disorders. Only a single layer of epithelial cells separates the luminal contents from effector immune cells in the lamina propria and the internal milieu of the body. Breaching this single layer of epithelium can lead to pathological exposure of the highly immunoreactive sub epithelium to the large number of foreign antigens in the lumen. In fact, breached TJ integrity is observed in multiple infectious, autoimmune and allergic diseases. It was suggested that commonly used industrial food additives play a major part in increased intestinal permeability. The seven food additives mentioned above [5-7], abrogate human epithelial barrier function and increase intestinal permeability through the opened TJ, enhancing the entry of foreign immunogenic antigens and activation of the sub-epithelial immune cascade [1,5-7].


Food Additives Breach Tight Junction (TJ) Integrity
Over recent decades, a significant increase in the incidence of chronic immune mediated diseases in industrialized countries has led to the postulation that diet is a potential environmental risk factor for such disorders.Only a single layer of epithelial cells separates the luminal contents from effector immune cells in the lamina propria and the internal milieu of the body.Breaching this single layer of epithelium can lead to pathological exposure of the highly immunoreactive sub epithelium to the large number of foreign antigens in the lumen.In fact, breached TJ integrity is observed in multiple infectious, autoimmune and allergic diseases.It was suggested that commonly used industrial food additives play a major part in increased intestinal permeability.The seven food additives mentioned above [5][6][7], abrogate human epithelial barrier function and increase intestinal permeability through the opened TJ, enhancing the entry of foreign immunogenic antigens and activation of the sub-epithelial immune cascade [1,[5][6][7].

Summary
Multiple food additives might be detrimental to human health, by inducing disequilibrium between the microbiota and dysbiota and by compromising the intestinal barrier mechanisms.Figure 1 summarizes the mechanism of increased intestinal permeability induced by food additives used in the processed food industries.P-80 is only one of them [1].Its emulsifying capacity join multiple additional pathways were intestinal protective mechanisms are disrupted.Further studies on the effects of industrial processed food additives on the intestinal ecosystem events, mucus integrity and intestinal permeability will impact on the food industry additive policy, food products labeling, consumer awareness, regulatory authorities and public health implementation.

Introduction
In the current issue of SOJ Microbiology & Infectious Diseases a frequently used emulsifying food additive: Polysorbate-80 (P-80) was shown to impact mouse microbiota, promote intestinal inflammation, obesity and liver dysfunction [1].Epidemiological data provide strong evidence of a steady rise in autoimmune and allergic diseases throughout westernized societies over the last decades [2].This trend parallels the recent pandemic of the metabolic syndrome and other lifestyle related human disorders [3,4].The present editorial will expand on additional food additives, used heavily in the processed food industries, which join P-80 as environmental inducers of chronic diseases.

Food Additive Consumption is Increasing
Living in western countries has a strong impact on nutritional habits collectively termed the "Western diet" including high fat, trans fatty acids, cholesterol, proteins, sugars, salt intake, as well as frequent consumption of processed and "fast food" [3].The net fold % increases/year of the 7 industrial food additives sales and consumption over the last 4-6 decades was summarized recently [5][6][7].As reported, in an increasing order, emulsifiers, salt, industrial food enzymes and nanoparticles are sold and consumed the most.

Food Additives Drive Human Microbiome towards Dysbiosis
The human gastrointestinal tract exhibits one of the highest densities of microorganisms on earth.Several studies have analyzed the microbiota in the large intestine showing that nutrition affects the intestine luminal bacteria, thus impacting the host's well-being.The question arises, if food additives impact the intestinal ecosystem?The absolute answer is positive.Glucose [8], salt [9], organic solvents [10], emulsifiers [1,11,12], gluten [13,14], microbial transglutaminase [5,6], and nanoparticles [15] impact the intestinal ecosystem, affecting the equilibrium between the microbiota and the dysbiota.

Figure 1 :
Figure 1: Mechanism of increased intestinal permeability induced by food additives used in the processed food industries.