Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient : A Case Report and Review of the Literature

Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient: A Case Report and Review of the Literature FZ Henniche1*, A. Chabani1, A. Zerouki1, H. Ziane2 and D. Bacha3 1Laboratoire de microbiologie, Hôpital Central de l’Armée Mohamed Seghir Nekkache, Algiers, Algeria 2Laboratoire de microbiologie, Hôpital Mustapha-Bacha Algiers, Algeria 3Service des maladies infectieuses et tropicales, Hôpital Central de l’Armée Mohamed Seghir Nekkache, Algiers, Algeria SOJ Microbiology & Infectious Diseases Open Access Case report


Introduction
The purulent pericarditis is a rare but severe and sometimes fatal pathology.The mortality linked at the risk of tamponnade, can reach 30% [1].
The purulent pericarditis is rarely primitive.It is most of the time the complication of the infection of neighborhood [2].
During staphylococcal sepsis, the secondary localizations are frequent.The cardiac attainment is noted in 8 to 25 % of the cases and it is essentially endocarditic [2].
We report a case of peculiar sepsis, individual by its localization to the pericardium, its hematogenous contamination, the nature of the responsible germ Community Acquired -Staphylococcus Aureus Methicillin-Resistant (CA -MRSA) and especially the later discovery of an infection HIV in a patient with type 2 diabetes.

Case report
A 66-year-old Woman, diabetic type 2 with preexisting infected cyst mammary and fistula to the skin, was received in the emergency care unit of the Central Hospital of the Army but the culture was negative.Ciprofloxacin was indicated, justified by the good osseous distribution of fluoroquinolones.Seen her favorable evolution, the patient had gone out in the 15 th day with fixed immobilization of 02 joints and stoppage of the vancomycin.The treatment by the ciprofloxacin was maintained for 03 months.
Six months later, the patient was readmitted for respiratory distress syndrome with altered general state.The radiography of lungs showed images of atypical pneumonia evoking a pneumocystosis and motivating a request of serology HIV.Two tests HIV 1 and 2, realized by 02 different ELISA (Enzygnost VIH Integral II Siemens R-Genscreen HIV Ag-Ac BioradR) gave positive results (DO out of range).A Western blot (New lav blot 1 BioradR) HIV 1 was made on a second serum and confirmed the infection by HIV 1 (all the proteins HIV 1 were found).

Discussion
The initial diagnosis retained at our patient was a sepsis with pericardial and articular localization.The site of entry would be a staphylococcal cutaneous infection of mammary localization.Clinically, no risk factor has been found at this patient's except the diabetes.But it was not a being argument enough for explaining the pericardial localization.No biological exploration in search of an Immunosuppression (serology HIV or other one) was made before the episode of the lung infection.
The primitive infection of the pericardium is rare and the purulent pericarditis is most often occurs as a direct extension of infection from an adjacent tissues (pneumonia, pleural, mediastinal or diaphragmatic) [1].It can result from a penetrating trauma of the pericardium or complicate cardiac surgery and also be of hematogenous origin from a distant infectious focus (otorhinolaryngology especially at the child) [1,2].

Streptococcus pneumoniae, Haemophilus influenzae and
Neisseria meningitidis are bacteria the most frequently incriminated [1].
The infection by the HIV increased the incidence of pericarditis [3].In African series, it is estimated from 25 to 35 % [3].For etiologies, the tuberculosis is the most frequent, but viruses (Cytomegalovirus CMV) or parasites (Cryptococcus neoformans) can be incriminated [3,4].
Six cases of pericarditis due to S.aureus at patients affected by HIV were the object of publications.In every case the bacteriological proof is brought by the culture of the pericardial fluid.The site of entry was not identified in the majority of the cases, suggesting the responsibility of the nasal porterage [4,5].Some authors also evoke as risk factors a cutaneous infection or a use of intravenous catheter [5].For our patient, the existence of a cutaneous infection was considered as a possible site of entry.Furthermore, at our patient the diabetes and the hyperglycemia could be factors stressing the general and local Immunosuppression and favoring the microbial multitude.All the patients had presented pneumonia to Pneumocystis carnii or to CMV, sarcomas of Kaposi before or after the episode of the pericarditis.For the evolution, 3 patients died from pneumonia, other one of a tamponnade.Our patient had also died further to a pneumonia.It seems that in every case reported, the HIV infection was already known, contrary to our patient where the pericarditis arose while the HIV infection was not diagnosed yet.
For the strains of S. aureus, one was Methicillin-resistant, another Methicillin-sensible and without precision for the other cases.
Three other cases of pericarditis due to S. aureus not bound to an HIV infection were also published.The first was reported by Charles O. Onyeama and al, at a child in malnutrition [1], the author connects the pericarditis with a lung infection.The second case is reported by M. Schouten in the patient with a tubercular calcified pericarditis.He was working in a slaughterhouse [6].The author supposes an iatrogenic origin by direct inoculation during a pericardiocentesis.The strain was a typical SARM t011 animal-derived, of which the patient was carrier [6].The third case is described by L. Gillet and all at a child having presented simultaneously a pneumonia and empyema [7].In this case, the authors suppose that it is the first strain (CA-MRSA) isolated from pericardium producing PVL [7].Our strain would be the second one.
S. aureus is one of the main pathogenic agents for the man.It possesses an impressive arsenal of factors of virulence [8].The most characteristic both genetic elements of the CA-MRSA are the presence of the genes coding the PVL, the nature of the chromosome cassette which carries the resistance in beta lactam agents of type IV more rarely V but never of type I, II or III privilege of the hospitable MRSA [8].The CA-MRSA producing PVL is responsible for cutaneous infections in 90 to 95 % of the cases, sometimes of pyomyositis and osteomyelitis as well as for other invasive locations such as the necrotizing pneumonias and the severe sepsis [9].In Algeria, the highest rate of infection by producing strains of PVL reached 67.2 % [10].
HIV infected patients are recognized as one of these higher risks groups due to increased rates of both MRSA colonization and infection [11].The organism's interactions and disease manifestations with the immunocompromised host are expected to be complex and involve defects in innate immunity.Chemo taxis, neutrophil phagocytosis and intracellular killing are vital steps in host defense against S. aureus [11].Some studies showed significant dysfunctions concerning these elements in persons with HIV [11].
The treatment of the purulent pericarditis has to associate prematurely an antibiotic treatment and a surgical drainage [3].The pericardial constriction is a rare complication, it is unpredictable and of arisen insidious after variable deadline going of a few weeks in several years [3].A late diagnosis and treatment are two main predictive factors of this complication.Some authors think that the risk is particularly higher if the responsible germ is S. aureus or Haemophilus influenzae and

Conclusion
The CA-MRSA is more frequently incriminated in invasive infections committing seriously the prognosis for survival.Its isolation from a pericardial liquid testifies of its virulence and its important pathogenic power.During the staphylococcal infections, the risk of appearance of secondary infectious focus of more marked gravity, especially in the presence of factors of comorbidity (cancer, chronic pathology, state of Immunosuppression), requires a rigorous coverage of these infections.But, on the other hand, for an unusual localization of this germ, it would be imperative to look for a state of Immunosuppression, even latent, in particular an infection HIV.
Patient: A Case Report and Review of the Literature Copyright: © 2017 Henniche, et al.they propose a pericardiectomy or the association of a local fibrinolysis[3].To avoid this complication, regular ultrasound checks are indicated.