Clinical Medical Images Open Access
A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiation
Alireza Heidari*
Received: November 10, 2017; Accepted: November 27, 2017; Published: November 30, 2017
Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA
*Corresponding author: Alireza Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA, E–mail : @; @
Citation: Alireza Heidari (2017) A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiation. Cancer Sci Res Open Access 4(2): 1-8. DOI: http://dx.doi.org/10.15226/csroa.2017.00137
In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of white synchrotron radiation using different analysis methods and techniques such as X–Ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), Attenuated Total Reflectance Fourier Transform Infrared (ATR– FTIR) spectroscopy, Raman spectroscopy, Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA) and Energy–Dispersive X–Ray Spectroscopy (EDX). It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under white synchrotron radiation with the passage of time (Figures 1–8) [1– 109].

It can be concluded that malignant human cancer cells and tissues have gradually and clearly transformed to benign human cancer cells and tissues under white synchrotron radiation with the passage of time (Figures 1–8) [1–109]. It should be noted that malignant human cancer cells and tissues were exposed under white synchrotron radiation for 30 days. Furthermore, there is a shift of the spectrum in all of spectra after irradiating of synchrotron radiation that it is because of the malignant human cancer cells and tissues shrink post white synchrotron irradiation with the passage of time. In addition, all of the figures are related to the same human cancer cells and tissues.
Figure 1: X–Ray Diffraction (XRD) analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time. It should be noted that y–axis shows intensity (a.u.) and also x–axis shows 2–theta (degrees) in this figure [1–109]
Figure 2: Transmission Electron Microscopy (TEM) images of malignant cancer cells and tissues in 200 (nm) (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1–109]
Figure 3: Atomic Force Microscopy (AFM) images of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1–109]
Figure 4: Scanning Electron Microscopy (SEM) images of malignant cancer cells and tissues in 200 (nm) (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1–109]
Figure 5: Attenuated Total Reflectance Fourier Transform Infrared (ATR–FTIR) spectra of malignant cancer cells and tissues before (red spectrum) and after (black spectrum) irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time. It should be noted that y–axis shows absorbance and also x–axis shows wave number (cm–1) in this figure [1–109]
Figure 6: Raman spectra of malignant cancer cells and tissues before (red spectrum) and after (black spectrum) irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1–109]
Figure 7: Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA) analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time. It should be noted that y–axis shows Hydrogen released (wt. %) and at the same time Endo. Exo. transition and also weight loss/ (%) and at the same time heat flow (a.u.). Also, x–axis shows temperature (°C) in this figure [1–109]
Figure 8: Energy–Dispersive X–Ray Spectroscopy (EDX) analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1–109]
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  84. Alireza Heidari. Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat High Cholesterol and Related Conditions and to Prevent Cardiovascular Disease under Synchrotron Radiation. J Pharm Sci Emerg Drugs.  2017;5:1. DOI: 10.4172/2380-9477.1000e104
  85. Alireza Heidari. Non–Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams. J Cell Biol Mol Sci. 2017;2(1):1-5.
  86. Alireza Heidari. Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood–Brain Barrier (BBB) Translocation to Targeted Deliver Anti–Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation. J Nanotechnol Material Sci. 2017;4(2):1–5.
  87. Ricardo Gobato. Alireza Heidari. Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi. American Journal of Quantum Chemistry and Molecular Spectroscopy. 2017;2(3):37-46. Doi: 10.11648/j.ajqcms.20170203.12
  88. Alireza Heidari. Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti–Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiations. J Med Oncol. 2017;1(1):1-2.
  89. Alireza Heidari. A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation. Am J Ethnomed. 2010;4(1):1-4.
  90. Alireza Heidari. An Investigation of the Role of DNA as Molecular Computers: A Computational Study on the Hamiltonian Path Problem. International Journal of Scientific & Engineering Research. 2014;5(1):1884-1889.
  91. Alireza Heidari. Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood– Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. J Med Chem Toxicol. 2017;2(3):1-5.
  92. Alireza Heidari. Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti–Microbial Agents and Anti–Cancer Nano Drugs in Nanomedicines Based Drug Delivery Systems for Anti–Cancer Targeting and Treatment. Parana Journal of Science and Education (PJSE). 2017;3(4):10-19.
  93. Alireza Heidari. A Comparative Computational and Experimental Study on Different  Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open J Anal Bioanal Chem. 2017;1(1):014-020.
  94. Alireza Heidari. Combination of DNA/RNA Ligands and Linear/Non–Linear Visible–Synchrotron Radiation– Driven N–Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti–Cancer Activity. Enz Eng. 2017;6:1. DOI: 10.4172/2329-6674.1000160
  95. Alireza Heidari. Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta–2 Transferrin and Bacterioferritin–Based Anti–Cancer Nano Drugs Encapsulating Nanosphere as DNA–Binding Proteins from Starved Cells (DPS). Mod Appro Drug Des. 2017;1(1):1-5.
  96. Alireza Heidari. Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells. J Proteomics Enzymol. 2017;6:1. Doi: 10.4172/2470-1289.1000e109
  97. Alireza Heidari. Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti–Cancer Nanodrugs Delivery across the Blood–Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. J Pharm Pharmaceutics. 2017;4(2):1–5.
  98. Alireza  Heidari, Christopher  Brown. Combinatorial  Therapeutic  Approaches  to  DNA/RNA  and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti–Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Ann Adv Chem. 2017;1: 061-069.
  99. Alireza Heidari. Vibrational Spectroscopy of Nucleic Acids”, Wahid Ali Khan (Editor), “Basic Biochemistry”, Austin Publishing Group (APG)/Austin Publications LLC, ISBN: 978–0–9971499–2–0, Pages 1–18, Jersey City, New Jersey, USA, 2016.
  100. Alireza Heidari. High–Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation.  J Transl Res. 2017;1(1):1-3
  101. Alireza Heidari. Investigation of Anti–Cancer Nano Drugs’ Effects’ Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X–Ray Radiations with the Passage of Time Using Mathematica. Current Trends Anal Bioanal Chem. 2017;1(1):36-41.
  102. Alireza Heidari. Pros and Cons Controversy on Molecular Imaging and Dynamics of Double–Standard DNA/RNA of Human Preserving Stem Cells–Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium–4 Nucleus (Alpha Particle) Using Synchrotron Radiation. Arch Biotechnol Biomed. 2017;1(1):067-0100.
  103. Alireza Heidari. Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR Spectroscopy and Self–Organizing Maps under Synchrotron Radiation. SOJ Mater Sci Eng. 2017;5(2):1-6.
  104. Alireza Heidari. Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Challenges Cancer Detect Ther. 2017;4(2):e001.
  105. Alireza Heidari. Laser Spectroscopy, Laser–Induced Breakdown Spectroscopy and Laser–Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Hepatol Gastroenterol, 2017;3(4):079-084.
  106. Alireza  Heidari. Time–Resolved  Spectroscopy  and  Time–Stretch  Spectroscopy  Comparative  Study  on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Pharmacovigilance and Drug Safety. 2017;4 (2):e001.
  107. Alireza Heidari. Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation. Open J Anal Bioanal Chem. 2017;1(1):021-026.
  108. Alireza  Heidari. Electron Phenomenological Spectroscopy, Electron Paramagnetic Resonance (EPR) Spectroscopy and Electron Spin Resonance (ESR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Austin J Anal Pharm Chem. 2017;4(3):1091.
  109. Alireza Heidari. Therapeutic Nanomedicine Different High–Resolution Experimental Images and Computational Simulations for Human Brain Cancer Cells and Tissues Using Nanocarriers Deliver DNA/RNA to Brain Tumors under Synchrotron Radiation with the Passage of Time Using Mathematica and MATLAB. Madridge J Nano Tech. Sci. 2017;2(2):77–83.
 
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