Editorial Open Access
Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and31P NMR Spectroscopy and Self–Organizing Maps under Synchrotron Radiation
Alireza Heidari*
Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA
*Corresponding author: Alireza Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA E-mail: @; @
Received: November 13, 2017; Accepted: November 20, 2017; Published: November 22, 2017
Citation: Alireza Heidari (2017) Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo 1H or Proton NMR, 13C NMR, 15N NMR and31P NMR Spectroscopy and Self–Organizing Maps under Synchrotron Radiation. SOJ Mater Sci Eng 5(2): 1-6.
EditorialTop
In the current study, visualizing metabolic changes in probing human cancer cells and tissues metabolism using vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self– organizing maps under synchrotron radiation was investigated. Cadmium Oxide (CdO) based Nano membranes have received a growing interests to the separation and purification of human cancer cells and tissues [1–48]. Human cancer cells and tissues are most experimentally diagnosed nowadays using vivo 1H or proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self– organizing maps under synchrotron radiation, a reaction between Cadmium Oxide (CdO) nanoparticles and human cancer cells and tissues, using vivo 1H or proton NMR, 13C NMR, 15N NMR and 31P NMRspectroscopy and self–organizing maps under synchrotron radiation [49–89]. Selective removal of human cancer cells and tissues in a selective Nano membrane reactor enables the human cancer cells and tissues diagnosis using vivo 1Hor proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self–organizing maps under synchrotron radiation [90–100]. Numerous methods have been proposed to deposit Cadmium Oxide (CdO) Nano films on porous supports. Among them, electroless plating is an autocatalytic electrochemical reaction that offers the flexibility to apply very thin, conformal and continuous coatings to a variety of porous or non–porous supports. In this editorial, Cadmium Oxide (CdO) Nano membranes by different contents of Gold (Au) nanoparticles were prepared by sequential electroless plating technique and were characterized by vivo 1H or proton NMR, 13C NMR , 15N NMR and 31P NMR spectroscopy and self–organizing maps under synchrotron radiation. The Cadmium Oxide (CdO) – Gold (Au) Nano membranes with different contents of Gold (Au) nanoparticles was subjected to different annealing conditions to promote diffusion and distribution of elements to form an alloy matrix. The obtained results revealed that increasing in annealing time enhances the homogeneity of alloy and lead to obtain a totally uniform alloy after 36h annealing at 785°C which was confirmed by compositional profiles. In addition, altering the Gold (Au) nanoparticles content of the alloy changed the morphology and it seems to be intended to have a dendritic morphology by increasing in Gold (Au) nanoparticles content. The Human cancer cells and tissues permeation through the prepared membranes increased substantially with increasing the temperature, but the separation factor is slightly decreased.

Cadmium Oxide (CdO) nanoparticles is the best–known electrocatalysts for the cancer toxicity reduction reaction. This editorial relates to electroless autocatalytic plating of Cadmium Oxide (CdO) nanoparticles onto a Nano membrane for visualizing metabolic changes in probing human cancer cells and tissues metabolism using vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self–organizing maps under synchrotron radiation. Cadmium Oxide (CdO) nanoparticles plating involves the deposition of a Cadmium Oxide (CdO) nanoparticles coating from an aqueous bath onto a substrate by a controlled cancer toxicity reduction reaction which is catalyzed by the metal being deposited or reduced. The catalytic activity of Cadmium Oxide (CdO) nanoparticles depends on the procedure used to prepare the electrocatalysts, the size of Cadmium Oxide (CdO) nanoparticles and the surface roughness of Nano membrane. Nano surfaces were catalytically active by immersion Nano membranes in Cadmium Oxide (CdO) nanoparticles solution. By pressing Cadmium Oxide (CdO) nanoparticles– coated Nano membrane on diffusion electrode layer new method suggested to visualize metabolic changes in probing human cancer cells and tissues metabolism using vivo 1H or Proton NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy and self–organizing maps under synchrotron radiation. The mass of Cadmium Oxide (CdO) nanoparticles deposited and the Cadmium Oxide (CdO) nanoparticles surface area were mainly affected by the reactant concentration, the deposition time and the temperature. Cadmium Oxide (CdO) nanoparticles loading of the optimum condition was 0.385 mg/cm2. The catalyst structure was characterized via vivo 1H or proton NMR, 13C NMR, 15N NMR and 31P NMRspectroscopy and self–organizing maps under synchrotron radiation. Biospectroscopic results showed that Cadmium Oxide (CdO) nanoparticles layer can be attached closely and firmly to Nano membrane. Furthermore, biospectroscopic results indicated that strong peak correspond to crystalline facet. The mean grain size of the Cadmium Oxide (CdO) nanoparticles was 110 (nm). The electrocatalytic activity of the catalysts toward cancer toxicity reduction reaction was investigated by means of Linear Sweep Voltammetry (LSV). The biospectroscopic results also illustrate that placing a Cadmium Oxide (CdO) nanoparticle monolayer on a Nano membrane is an attractive way of designing better cancer toxicity reduction electrocatalysts with very low Cadmium Oxide (CdO) nanoparticles contents for visualizing metabolic changes in probing human cancer cells and tissues metabolism using vivo 1H or Proton NMR, 13C NMR, 15N NMRand 31P NMR spectroscopy and self–organizing maps under synchrotron radiation.
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  92. Heidari A. Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti–Microbial Agents and Anti–Cancer Nano Drugs in Nanomedicines Based Drug Delivery Systems for Anti–Cancer Targeting and Treatment. Parana Journal of Science and Education (PJSE). 2017;3(4):10–19.
  93. Heidari A. A Comparative Computational and Experimental Study on Different Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open J Anal Bioanal Chem. 2017;1(1):014–020.
  94. Heidari A. Combination of DNA/RNA Ligands and Linear/Non–Linear Visible–Synchrotron Radiation– Driven N–Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti–Cancer Activity. Enz Eng. 2017;6(1).
  95. Heidari A. Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta–2 Transferrin and Bacterioferritin–Based Anti–Cancer Nano Drugs Encapsulating Nanosphere as DNA–Binding Proteins from Starved Cells (DPS). Mod Appro Drug Des. 2017;1(1).
  96. Heidari A. Potency of Human Interferon β–1a and Human Interferon β–1b in Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells. J Proteomics Enzymol. 2017;6(1).
  97. Heidari A. Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti–Cancer Nanodrugs Delivery across the Blood–Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. J Pharm Pharmaceutics. 2017;4(2):1–5.
  98. Heidari A, Brown C. Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsalicylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/RNA to Targeted Nano Drugs for Enhanced Anti–Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems.  Ann Adv Chem. 2017;1(2):061–069.
  99. Heidari A. Vibrational Spectroscopy of Nucleic Acids, Wahid Ali Khan (Editor), Basic Biochemistry. Austin Publishing Group (APG)/Austin Publications LLC. 2016:1–18.
  100. Heidari A. High–Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation. J Transl Res. 2017;1(1):1–3.
 


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