Case Report
Open Access
Benign Solitary Fibrous Tumor Growth in the Wall
of Urinary Bladder, Reporting Two New Cases from
Yemen
Khaled M. Al-Kohlany1*, Waheeb R. Al-Kubati2*, Husam A. Alhamss1 and Eman Al-Salami3
1 Associate professor of urology department, General Military Hospital and Medical college- Sana’a University-Yemen
2Consultant of general and colorectal of surgical department, Al-Thawrah Modern General Hospital, and Medical college- Sana’a University
3Consultatnt Pathologist Department, Alma moon diagnostic centre and Sana’a University, medical college, Sana’a- Yemen
2Consultant of general and colorectal of surgical department, Al-Thawrah Modern General Hospital, and Medical college- Sana’a University
3Consultatnt Pathologist Department, Alma moon diagnostic centre and Sana’a University, medical college, Sana’a- Yemen
*Corresponding author: Khaled M. Al-Kohlany- MD Associate professor of urology in medical College – Sana’a University Consultant & Head of
Urology Department General Military Hospital- Sana’a Tel: 00967- 777141014; P.O. Box: 314 – Altahreer post-office-Sana’a E-mail:
@
Waheeb R Al-Kubati MBBS, JBS, ABS, MRCSI1. Consultant general and colorectal surgery, Sana’a & 21st september university, E-mail:@
Waheeb R Al-Kubati MBBS, JBS, ABS, MRCSI1. Consultant general and colorectal surgery, Sana’a & 21st september university, E-mail:
Received: July 11, 2019; Accepted: September 2, 2019; Published: September 5, 2019
Citation: Kohlany KM, Kubati WR, Husam AA, Eman S, (2019) Benign Solitary Fibrous Tumor Growth in the Wall of Urinary Bladder,Reporting Two New Cases from Yemen. J UrolNephrol Open Access 5(1): 1-5. DOI: 10.15226/2473-6430/5/1/00145
A solitary fibrous tumor (SFT) of the urinary bladder is a rare
tumor with only 25 reported cases in the English literature. Because
of its rarity and variable clinical presentation, diagnosis and treatment
of these tumors represent a real challenge. Although in most of the
cases, the tumor has benign behavior, malignant presentation and
co-association with other malignant tumors have been reported
also. The diagnosis relies mainly on immunohistochemical staining
of the specimen. Proper histological diagnosis is very important as
the treatment approach is quite different from malignant bladder
tumors. Herein, we report about 2 new cases with SFT presented to
us in different periods with different clinical scenarios. In both cases,
we faced challenges in diagnosis and treatment for which we are
reporting.
Keywords: Solitary fibrous tumor; urinary bladder tumors; rare tumors; spindle cell tumors;
Keywords: Solitary fibrous tumor; urinary bladder tumors; rare tumors; spindle cell tumors;
solitary fibrous tumor (SFT) is a rare benign mesenchymal
tumor which had been described first as pleural tumor [1]. Later
on, it showed to have extra-pleural presentation including urinary
tract system. The 1st report about urinary bladder involvement
was in 1997 [2]. And since then only 25 cases were reported in
the English literature [3, 4]. Because of its rarity, large tumor
size and the unusual presentation, the tumor may be confused
with other malignant soft tissue tumors mainly sarcomas thus
representing diagnostic and therapeutic challenge [3, 4]. The
pathological diagnosis usually shows spindle cell tumor and
the final diagnosis is confirmed only by immunohistochemical
staining which confirms the presence of specific cellular markers
for fibrous tissue [5, 6]. Here we present 2 new cases of SFT of
the urinary bladder presented with different scenarios and
represented for us diagnostic and therapeutic challenge.
A 45-year-old female who presented complaining of recurrent
painless hematuria associated with dull left loin pain for several
months. Radiological evaluation revealed large mass 7x5cm in the
left lateral bladder wall causing severe left hydroureteronephrosis
with loss of parenchymal thickness (Figure 1). Cystoscopy showed
a solid mass in the left lateral wall with intact smooth mucosal
surface and non-visualized left ureteric orifice. Transurethral
resection of the bladder tumor (TURBT) was done for biopsy
purpose. This, unfortunately, was complicated by bladder
perforation which was not recognized during the procedure and
picture of acute abdomen developed on the 3rd day. We were in
a critical situation as we don’t have a pathological diagnosis yet
and have a serious complication. We contacted the pathologist
for quick diagnosis and it showed benign spindle cell tumor with
the recommendation for immunohistochemical staining for more
confirmation. We proceeded to immediate laparotomy. Peritoneal
lavage was performed first and then the bladder was opened and
the tumor was easily enucleated and the bladder perforation
was repaired. The definitive histopathology confirmed the
diagnosis of a solitary fibrous tumor of the urinary bladder by
immunohistochemical staining. The patient passed a smooth
postoperative period with favorable follows up.
A 30-year-old non-married male presented with obstructive
and irritative lower urinary tract symptoms (LUTS), deep pelvic
and lower limbs pain, and general fatigue, loss of appetite and
difficulty of defecation. Primary ultrasound study showed large
pelvic mass with bilateral hydronephrosis. Computed tomography
(CT) showed large enhancing pelvic mass 12x8cm protruding
into the bladder cavity and compressing the rectum posteriorly
(figure 2a) and causing bilateral hydroureteronephrosis more on
the right side. Digital rectal examination (DRE) under anesthesia
revealed large pelvic mass filling the rectum with limited
mobility. Cystoscopy showed large mass deviating the prostatic
urethra and bulging inside the bladder cavity with smooth
intact surface preventing adequate movement and examination
of the bladder cavity. TUR biopsy was taken and the pathology
after immunohistochemistry showed solitary fibrous tumor of
the urinary bladder with positive tissue markers CD 99, CD 34,
BCL2, very low proliferation index ki-67 and negative for S-100
and Action. After consultation with the colorectal surgeon, the
decision was for surgical excision. The tumor was filling the
pelvic cavity but fortunately, it was easily enucleated through
midline transperitoneal and trans-vesicle approach. Its weight
was 376g and length was 11x7cm (Figure 2b). After excision,
both orifices were identified and bilateral DJ stents were inserted.
The patient passed a smooth postoperative course and the final
histopathology also confirmed the diagnosis of SFT.
Figure 1:CT scan abdomen showed a solid mass in the left lateral wall with intact smooth mucosal surface and non-visualized left ureteric orifice.
Figure 2a:CT scan abdomen showed large pelvic mass with bilateral hydronephrosis
Figure 2b:Showed the tumor was filling the pelvic cavity. Its weight was 376g and length was 11x7cm
The rare incidence and the variable nonspecific presentation
of solitary fibrous tumor of the urinary bladder are behind
the confusion and challenge in patients who present with this
tumor. In many cases, the tumor origin couldn’t be defined
precisely and usually the 1st primary diagnosis comes to mind
is pelvic sarcoma [3, 4]. Because of this confusion, proper preoperative
pathological diagnosis is of utmost importance for
proper planning of the treatment which in most of the cases is
organ sparing surgical excision avoiding any unnecessary radical
interventions.
In 2016, Tanaka et al reported 2 new cases and reviewed all previously reported 22 cases. They found different clinical presentation according to the size and location of the tumor. These include voiding LUTS in 36%; hematuria in 32%, incidental finding on imaging in 18%; and lower abdominal discomfort in 14% [3].
After this report, only one case was reported in 2017 and with our report, the total number of reported patients with SFT of the urinary bladder will be 27 cases [4]. The para-neoplastic syndrome has been described for the tumor mainly with hypoglycemia due to insulin-like growth factor production by the tumor. It resolves after surgical excision of the tumor [5, 7]. Our patients presented with mixed irritative and obstructive LUTS because of the location and large size of the tumors that occlude the bladder outlet. In addition hematuria developed in the first patient.
The main important diagnostic tool is immunohistochemical staining of the tumor for the detection of specific cellular markers. These include BCl-2, CD34 (90– 95%), CD99 (70%), and vimentin [6, 3]. In the 1st case of our patients, the diagnosis of the biopsy specimen was benign spindle cell tumor and no immunohistochemistry was done because the patient developed an acute abdomen and we had to operate on her. However final histopathology confirmed the diagnosis with immunohistochemistry with positive cellular markers for SFT. The 2nd case was managed better and the diagnosis was confirmed in the biopsy specimen which was positive for CD 99, CD 34 and BCL2 and negative for other tumors.
The recommended treatment approach for SFT of the bladder is different. Because of the large size, deep pelvic location with the uncertain origin of the tumor, unclear preoperative diagnosis or there is suspicion to be malignant, open surgical excision of the tumor with bladder preservation is the most commonly reported approach [3, 4, 8].
Nevertheless, if the tumor is of average size, in a suitable location inside the bladder and the diagnosis is confirmed histological, TURBT is the preferred less invasive treatment approach. However, repeated TURBT may be needed for residual or recurrent tumor [9]. The 1st case of our patients might be suitable for TURBT if the diagnosis was confirmed and no complication developed. The 2nd case was typical for open surgical intervention because of the large size and deep pelvic location of the tumor.
Despite its benign course in most of the cases, SFT may have malignant behavior in 10-20% of cases [3]. Cheng et al, 2012 reported about malignant SFT of the bladder which required excision and partial cystectomy with favorable outcome [8]. Thus, the prognosis of the disease is favorable in most of the reports with long term follow up approaching 10 years in one report [3]. However, malignant variants and co-association of other malignancies should be considered [8, 3, and 10]. This may require adjuvant chemotherapy and close follow up.
In 2016, Tanaka et al reported 2 new cases and reviewed all previously reported 22 cases. They found different clinical presentation according to the size and location of the tumor. These include voiding LUTS in 36%; hematuria in 32%, incidental finding on imaging in 18%; and lower abdominal discomfort in 14% [3].
After this report, only one case was reported in 2017 and with our report, the total number of reported patients with SFT of the urinary bladder will be 27 cases [4]. The para-neoplastic syndrome has been described for the tumor mainly with hypoglycemia due to insulin-like growth factor production by the tumor. It resolves after surgical excision of the tumor [5, 7]. Our patients presented with mixed irritative and obstructive LUTS because of the location and large size of the tumors that occlude the bladder outlet. In addition hematuria developed in the first patient.
The main important diagnostic tool is immunohistochemical staining of the tumor for the detection of specific cellular markers. These include BCl-2, CD34 (90– 95%), CD99 (70%), and vimentin [6, 3]. In the 1st case of our patients, the diagnosis of the biopsy specimen was benign spindle cell tumor and no immunohistochemistry was done because the patient developed an acute abdomen and we had to operate on her. However final histopathology confirmed the diagnosis with immunohistochemistry with positive cellular markers for SFT. The 2nd case was managed better and the diagnosis was confirmed in the biopsy specimen which was positive for CD 99, CD 34 and BCL2 and negative for other tumors.
The recommended treatment approach for SFT of the bladder is different. Because of the large size, deep pelvic location with the uncertain origin of the tumor, unclear preoperative diagnosis or there is suspicion to be malignant, open surgical excision of the tumor with bladder preservation is the most commonly reported approach [3, 4, 8].
Nevertheless, if the tumor is of average size, in a suitable location inside the bladder and the diagnosis is confirmed histological, TURBT is the preferred less invasive treatment approach. However, repeated TURBT may be needed for residual or recurrent tumor [9]. The 1st case of our patients might be suitable for TURBT if the diagnosis was confirmed and no complication developed. The 2nd case was typical for open surgical intervention because of the large size and deep pelvic location of the tumor.
Despite its benign course in most of the cases, SFT may have malignant behavior in 10-20% of cases [3]. Cheng et al, 2012 reported about malignant SFT of the bladder which required excision and partial cystectomy with favorable outcome [8]. Thus, the prognosis of the disease is favorable in most of the reports with long term follow up approaching 10 years in one report [3]. However, malignant variants and co-association of other malignancies should be considered [8, 3, and 10]. This may require adjuvant chemotherapy and close follow up.
Despite its extremely rare incidence, the solitary fibrous
tumor of the urinary bladder should be put in the differential
diagnosis of any bladder or pelvic mass which looks well
circumscribed on radiological imaging. Clinical suspicion and
good communications with radiologists and pathologists are the
main clue for proper diagnosis and good planning for treatment.
For our colleagues Dr. Noman Al lahabi and Dr. Waheeb Al-
Kubati from surgical departments for their assistance in the
surgical management of these patients. The authors would like
to thank Dr. Ali Ahmed Al-Zaazaai, M.Sc. Clinical Pharmacy from
Wenzhou Medical University, Wenzhou Zhejiang Province, PR
China who helped in arranging this paper for publish.
Statement of Ethics
The authors have no ethical conflicts to disclose.
Disclosure statements
The authors have no conflicts of interest to declare.
Khaled M. Al-Kohlany: Idea of the manuscript, writing and
literature review.
Waheeb R. Al-Kubati: Revision and supervision of the manuscript
Husam A. Alhamss: Data collection, literature review.
Eman Al-Salamy: Pathological interpretation, supervision of the manuscript.
Waheeb R. Al-Kubati: Revision and supervision of the manuscript
Husam A. Alhamss: Data collection, literature review.
Eman Al-Salamy: Pathological interpretation, supervision of the manuscript.
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