Steve Fiering Dartmouth Hitchcock Medical Center, USA
Steve Fiering is currently Professor of Microbiology/Immunology and Genetics at the Geisel School of Medicine at Dartmouth in the USA. Additional duties include directing the Dartmouth Transgenic and Genetic Construct Shared Resource that generates, supports the experimental use of transgenic mice, chairing the Institutional Animal Care and Use Committee for Dartmouth (IACUC). He has been at Dartmouth for 16 years. His graduate training was at Stanford in the lab of Len and Lee Herzenberg and postdoctoral studies were at the Fred Hutchinson Cancer Research Institute in Seattle where he trained with Mark Groudine.
Research in the Fiering lab focuses on developing novel approaches to stimulating antitumor immunity as cancer therapy. One current system uses nanoparticles of iron oxide and the heat they can generate when energized by an alternating magnetic field. Another area of current work is using attenuated Toxoplasma gondii to stimulate antitumor immunity by breaking immunosuppression mediated by the tumor. Additional lab activities include generating novel transgenic mouse cancer models.
His current research focus is on developing novel approaches to treating cancer with immunotherapy using preclinical models of cancer and developing new mouse cancer models. He also direct a transgenic mouse generation facility and Dart Mouse, a shared resource that supports speed congenic assays to facility changing the genetic background of transgenic animals.