Mini Review
Open Access
Osteoma cutis – Neoplasia or Paleogenetics?
Penev Julian1*, Ivan Krasnaliev2, Ilko Bakardzhiev3
1Department of Infection Diseases, and Dermatology, Medical University of Varna, Bulgaria
2Department of General and Clinical Pathology, Forensic Medicine, and Deontology, Medical University of Varna, Bulgaria
3Medical College, Medical Univerity of Varna, Bulgaria
2Department of General and Clinical Pathology, Forensic Medicine, and Deontology, Medical University of Varna, Bulgaria
3Medical College, Medical Univerity of Varna, Bulgaria
*Corresponding author: Julian Penev, MD, Associate Professor, Department of Infection Diseases, and Dermatology, Medical University of Varna,
Bulgaria, Tel:+3598888781833; E-mail:
@
Received: May 28, 2019; Accepted: June 5, 2019; Published: June 10, 2019
Citation: Penev J, Ilko B, Ivan K (2019) Osteoma cutis – Neoplasia or Paleogenetics?. Clin Res Dermatol Open Access 6(1): 1-3. DOI: http://dx.doi.org/10.15226/2378-1726/6/1/00185
Abstract
Osteoma cutis, also called multiple miliary osteoma cutis is a
rarely described dermatosis, and in cases that are not associated with
Albright’s hereditary osteodystrophy, osteoma cutis is being defined
as a skin type of hamartoma, with mesenchymal cell differentiation in
bone tissue. Levels of biochemical parameters (such as serum calcium,
alkaline phosphatase and parathormones) are usually within the
reference range when dermal osteomas are found. When osteoma cutis
formations are X-ray detected (as it often happens when a computer
tomography for dental purposes is performed) they manifest as small
nodules in the skin with bone density ranging from 1 to 3mm. The
very few presence in literature of osteoma cutis cases is due to the
fact that the condition is usually asymptomatic and/or its scarce
expression is misdiagnosed as milia, fatty hyperplasia or fatty cysts.
Reported in this paper are 14 (fourteen) cases of osteoma cutis. It is
discussed their occurrence is due to chronic inflammatory processes
(acne), and/or pathogenic behavior of skin injuring (patomimia) that
unlock suppressed genes (paleo genes) to protect the skin, that are
similar to the bone tiles (osteoderms) present in many vertebrates.
Key words: osteoma cutis; multiple miliary osteoma cutis; СО2 laser ablation; osteoderms;
Key words: osteoma cutis; multiple miliary osteoma cutis; СО2 laser ablation; osteoderms;
Abbreviations
[CO2] – Carbon Dioxide
Introduction
To our knowledge, relatively few cases of this particular
dermatosis are being discussed in literature. According to some
authors, 23 cases of osteoma cutis have so far been reported
in English literature [1]. Other authors inform on 35 cases of
osteoma cutis found in 20,000 consecutive skin biopsies [2].
It is known, that multiple miliary osteoma cutis is generally
considered as an uncommon condition [3], a rare benign disorder
[4], and miliary osteoma cutis is characterized by multiple bone
formations that occur predominantly on face, and in women
[8]. Our practice, however has proven osteoma cutis is not that
uncommon, and is often present also on the shoulder and back
area. We have accidentally come across osteoma cutis while
conducting routine laser removal procedures (deep fatty cysts,
and milia, etc.), (Figure 1) thanks to a purely physical process
which actually serves as a truly reliable osteoma cutis instant
diagnostic criteria: the ablation process stops as the laser beam
reaches the bone structure, and a bright, white, sparkling light
within the ablative channel is being observed. This is due to the
fact that calcium structure is slightly thermally-conductive and
thermally-resistant, and its point of contact with the infrared
laser beam is heated to a temperature exceeding 3000 Cо. There
is light radiation from the heated body. Quite interestingly, the
development of quantum physics began with Max Planck’s
pioneering insight of radiation law [5], namely describing the
radiation of light from a heated blackbody [6]. LASER itself is a
quantum physics creation. With the presence of foreign bodies
of mineral non-metallic matter (glass, porcelain, sand, slag)
in the skin a similar laser induced light illumination can be
observed. Skin Biopsy of extirpated osteomas were taken after
initial osteoma cutis cases were observed. Results demonstrated
Haversian canals, well-organized adult bone, as well as scarce
osteocytes, and osteoblasts [Figure 2].
Figure 1:Osteoma cutis
Figure 2:Histological view of osteoma cutis
Clinical cases and laser treatment methods of osteoma
cutis
Reported are 14 (fourteen) cases of osteoma cutis - 12
females and 2 males, with age ranging between 40 - 65 years.
Osteoma cutis formations were all unintentionally found in the
course of utpatient CO2 laser treatments over a three-year
period. In all 14 cases, osteoma cutis were accidentally detected
during the processes of laser removal of facial fatty cysts, as in
general several to ten bone formations were observed. However,
the formations extirpated from the shoulders and back of a 42 old
male patient were over 100 (Figure 3 and Figure 4).
Figure 3:Osteoma cutis found on shoulder area
Figure 4:Extirpated osteomas from the patient’s shoulder area. Dark
spots in the formations’ center are result of laser carbonization on the
surface of the structure
All 14 patients diagnosed with osteoma cutis were thoroughly
questioned regarding previous dermatological symptoms, as well
as other conditions that might be associated with occurrence of
such formations. Generally, in all cases, there were either issues
with acne in the past, or a persistent acne tarda. In some cases,
patients reported a daily, similar to auto-aggression behavior of
obsessive squeezing of pimples and comedones. The male patient
with multiple osteoma on his shoulders reported on constant
comedone squeezement actions performed on his shoulders
area by his girlfriend. Osteoma cutis are found on the face and
shoulders where no hairs are present. All osteoma cutis were
easily removed using a simple, proprietary CO2 laser technique,
different from a needle microincision–extirpation methodology
described by other authors [7], erbium: YAG laser procedures [8],
and surgical removal of discussed formations.
Figure 5:Dermoscopic view (X100) of extirpated osteoma cutis. Laser
beam’s carbonation zone (the dark spot) is clearly seen.
Figure 6:Comedone extracting tool
It does consist of the following 4 steps:
1. A small ablative hole with a maximum thin laser beam is done
into the nodule center until a brief bright light observed.
2. The laser hole is being cut in the direction of Langer’s lines orientation, with a length slightly less than the expected length of the osteoma.
3. Then, either performing a slight finger pressure or a comedone extracting tool (Figure 6) is used on the side of the cut until the osteoma pops out. It is easily done since osteoma cutis formations do not conglutinate with the surrounding dermal tissue.
4. The wound (2-3 mm) can be treated with a topical powder antibiotic, yet even if left untreated the wound epithelializes quickly with no visible scarring, as transient erythema persists for few weeks.
2. The laser hole is being cut in the direction of Langer’s lines orientation, with a length slightly less than the expected length of the osteoma.
3. Then, either performing a slight finger pressure or a comedone extracting tool (Figure 6) is used on the side of the cut until the osteoma pops out. It is easily done since osteoma cutis formations do not conglutinate with the surrounding dermal tissue.
4. The wound (2-3 mm) can be treated with a topical powder antibiotic, yet even if left untreated the wound epithelializes quickly with no visible scarring, as transient erythema persists for few weeks.
Discussion
This well-organized and differentiated tissue can not be
defined as a neoplastic (senso stricto) process since lesion
cellular structures are result of differentiation and control, and
not a neoplastic or metaplastic uncontrolled growth of mutated
cell line. Etiology of osteoma cutis has so far been described as
idiopathic. The presence of skin bone in all classes of vertebrate
organisms is not uncommon, and is being explained with
evolutionary defence mechanisms protecting the skin from injury
[9], Bone tiles in fish, some fossil amphibians, dinosaurs, reptilians
represent a similar histologically well-organized bone structure
that is species genetically determined, and called “osteoderms“
in biology, as well as in paleontology. In cladistics of birds and
mammals (except for the Cingulata order), defencive osteoderms
are not observed. Most likely, this is due to the replacement of
these defence functions by the development of keratin structures
- feathers in birds and hairs in mammals. A representative of
reptiles - Heloderma horidum has multiple bone formations
(osteoderms) in its skin. They serve to protect its skin from cacti
thorns, which are part of the habitat. (Figure 7). It is assumed that
even in Armadillos the presence of dermal bone structures also
serves to protect against the cacti thorns. Crocodile leather goods
(boots, suitcases) unless a replica, are osteoma abundant, and are
X-ray image observed in airport security inspections.
Figure 7:Heloderma horridum and Dasypus novemcinctus- typical representatives of species with well developed skin osteoderms
Conclusion
Osteoderms in Vertebrates are histologically identical to human
Osteoma cutis formations. It is likely that skin osteoma genes were
not lost in evolutionary terms but suppressed, and locked in the
genome. Chronic inflammation and pathogenic auto-aggression
are likely to trigger those locked protective palleogens in the
undifferenciated mesenchymal cells. With the increasingly frequent
use of laser ablative and non-ablative fractionated rejuvenation
procedures, mesotherapeutic pricks, and dermal rollers, the onset
of protective dermal osteogenesis may be observed in the future,
although such are not so far reported.
- Bouraoui S, Mlika M, Kort R, Cherif F, Lahmar A, Sabeh M. Miliary osteoma cutis of the face. J Dermatol Case Rep 2011;5(4):77-81.
- Burgdorf W, Nasemann T. Cutaneous osteomas: a clinical and histopathological review. Arch Dermatol Res 1977;260:121-135.
- Lahiry A. Multiple Miliary Osteoma Cutis of Face. J Cutan Aesthet Surg. 2018;11(2):95–97 doi:10.4103/JCAS.JCAS_54_17
- Alhazmi D, Badr F, Jadu F, Jan AM., Abdulsalam Z. Case Report: Osteoma Cutis of the Face in CBCT Images. Hindawi Case Reports in Dentistry. 2017;4. doi.org/10.1155/2017/8468965
- Planck, M. Vorlesungen über die Theorie der Wärmestrahlung.Johann Ambrosius Barth.1906.
- Planck, M.The Theory of Heat Radiation. Masius M. (transl.), (2nd edition). P. Blakiston's Son & Co. 1914.
- Baskan FB, Turan H, Tunali S, Toker SC, Adim SB, Bolka N. Miliary osteoma cutis of the face: treatment with the needle microincision–extirpation method. J Dermatol Treat. 2007;18(4):252-254. doi.org/10.1080/09546630701287878
- Hughes PSH. Miliary Osteomas of the Face Ablated with the Erbium: YAG Laser. Arch of Dermatology. 1999;135(4):378-80. DOI: 10.1001/archderm.135.4.378
- Larry M. Frolich. The Role of the Skin in the Origin of Amniotes Chapter 10. In Amniote Origins Editors: Martin S., Sumida K L M. Academic Press. 1997.327-352. DOI: 10.1016/B978-012676460-4/50011-1