Journal of Nutritional Health & Food Science

Author, Year

Animal Models of IBD

Route &Timing of Model

Dose

Duration of Resveratrol

Physical/Clinical Outcomes

Other Measured Outcomes

Abdallah et al., 2011^[21]

OXA in Wister albino rats

r.i., Day 1

10

7 days

↓ Ulcerative area

↓Wt. loss

↓Colon wt.

↓Histological score

↓MPO activity^a

↓MDA activity^a

↓1CAM-1^a

↓VCAM-1^a

↓LPO

↓NO^a

↓GSH^a

Abdin et al., 2013^[22]

100 T. gondii cysts in C57BL/10 mice

c.i., Day 1

10

14 day

↓Rectal bleeding

↓Diarrhea

↓Histological score

↓MPO activity^c

↓SphK1 activity^c

∄Capase-3 activity

Bereswill et al., 2010^[23]

DSS in male and female C57BL/6 mice

o.i., Day 3

10

10 day

↓Wt. loss

↓Bacteria translocation

↓Total Bacteria Load^a

↓Enterococci^c

↓E. Coli^c

↑Lactobacilli/ Bifidobacteria^a

↑Lt. of small intestines

↓IL-6^a

↓MPO-7^+a

↓MCP-1^a

↓IFN- γ^a

↑FOXP3^+a

↓CD3^+a

↑Ki-67+^b

↑IL-10^a

Cui et al., 2010^[28]

DSS in male and female C57BL/6J mice

o.i., First 7 days

42

70 days

↓Wt. loss

↑Colon lt.

↓CD3^+a

↓Neutrophils^b

↓COX-2^b

↓TNF-α^b

↓iNOS^b

↓p53^b

Larrosa et al., 2010^[41]

DSS in male Fischer F344rats

o.i., Last 8 days

2.1

29 days

↓E. Coli^a

↓Enterobacteria^a

∄Enterococci

∄Lactobacilli

∄Bifidobacteria

∄Clostridia

∄Wt. loss

∄Colon wt. & lt.

↓IL-6^a

↓Haptoglobin^a

↓Fibrinogen^a

↓TNF-α^a

↓MIG^a

↓MPIP-1γ^a

∄MPO

↑IL-10^a

Larrosa et al., 2009^[30]

TNBS in male Winstar rats

o.i., Last 5 days

1

25 days

↓Enterobacteria ^a

↓E. Coli ^a

↓Wt. loss^a

↓Histological score^b

∄Clostridia

↑Food intake^b

↑Colon lt.^b

↑Lactobacilli^c

↑Bifidobacteria^c

↓PGE₂ ^b

↓COX-2 ^b

↓NO ^b

↓PTGES ^b

∄Haptoglobin

∄Albumin

Martin et al., 2006^[25]

TNBS in male Winstar rats

c.i., Day1

10

14 days

↓Macroscopic damage score

↓Colon lt. & wt.

↓MPO activity ^b

↓TNF-α ^a

↓NF-κB p65 ^b

↓COX-2 ^b

∄COX-1

∄PGD₂

↑PGE₂^c

Martin et al., 2004^[24]

PG-PS in female Lewis rats

c.i., Day 3

10

4 days

↓Macroscopic damage score ^a

↓Wt. loss

↓Colon lt. & wt.

↓COX-2 in mucosa

↓IL-1β ^c

↓PGD₂^a

↓MPO ^a

∄PGE₂

Rahal et al., 2012^[38]

DSS in female C57BL/6 mice

b.i., Day 1

100

27 days

↓Histologic fibrosis score ^a

∄Wt. loss

↓IL-1β ^b

↓IL-6 ^a

↓TNF-α ^b

↓TGF- β1 ^b

Sanchez-Fidalgo et al., 2010^[13]

DSS in female C57BL/6 mice

o.i., Day 30

~3

30 days

↓Histological damage

↓Rectal bleeding ^c

↓Wt. loss ^a

↓Diarrhea ^c

↓Colon wt./lt. ^b

↓TNF-α ^a

↓IL-1β ^a

↓PGES-1 ^b

↓COX-2 ^a

↓iNOS ^a

↓p38 MAPK ^a

↑IL-10 ^a

Singh et al., 2010^[18]

IL-10 deficient female mice

o.i., for first 7 days

100*

14 days

↓Histological score

↑Wt. loss ^b

↑Colon lt.

↓SAA ^b

↓TNF-α ^b

↓IL-6 ^b

↓IL-1β ^b

↓IFN- γ ^b

↓COX-2 ^b

↓SIRT1 ^b

↓CD4^+b

↓CD11b+ cells b

Singh et al., 2012^[33]

DSS in male BALB/c mice

Naturally developed chronic colitis by day 126

100*

196 days

↓Wt. loss

↓Histological score

↓SAA ^a

↓IgA ^b

↓IgG ^b

↓IFN-γ ^a

↓TNF-α ^a

↓IL-6 ^a

↓RANTES ^a

↓IL-12 ^a

↓IL-1β ^a

↓CD4^+a

↑CD11b+ Gr-1+ ^a

Yao et al., 2010^[20]

DSS in male BALB/c mice

o.i., First 7 days

60

14 days

↓Histological score ^a

↓Disease activity index^a

↓MDA activity ^a

↓MPO activity ^a

↓TNF-α^a

↓IL-8 ^a

↓IFN-γ ^a

↓p22^{phox a}

↓gp91^{phox a}

↑SOD activity ^a

↑GSH-Px ^a

Yao et al., 2011^[15]

DSS in male BALB/c mice

o.i., First 7 days

35

14 days

↓Disease activity index^a

↓Histological score ^a

↓MPO activity ^a

↓NF-κB ^a

↓TNF-α ^a

↓IL-6 ^a

↓IL-1β ^a

Youn et al., 2009^[16]

DSS in male ICR mice

c.i., 7 days

10

7 days

↓Wt. loss ^a

↓Histological changes

∄Fluid intake

↑Colon lt. ^b

↓iNOS ^b

↓NF-κB

↓STAT3 ^b